Difference: GMT_4YP_20_2 (1 vs. 2)

Osseointegrated implants are a relatively new technique by which a limb replacement is directly attached to an existing bone, rather than held on via a cup over the residual soft tissue. These have many potential benefits, and it is known that indeed people reliably demonstrate osseointegration of the bone into such an implant. That means the bone is biologically responding and growing into the implant. However, it would be good to have better knowledge of 1) how does the cortical bone respond (increased density, increased thickness, localized remodeling, does the bone increase these factors only at specific point loading areas or does the load distribute well along the length of the implant and bone?) in response to the implant, 2) over what time do these changes tend to occur, and 3) are there at-risk areas due to implant positioning or geometry?